Biologics Discovery, Small Molecules, In Vitro Tox, Cellular Research
Biologics are one of the fastest growing therapeutic modalities today, and tools to increase the success in the discovery and development these important new medicines are desperately needed. IntelliCyt is developing a full suite of applications for the HTFC Screening System that solve the problems faced by scientists engaged in developing biotherapeutics.
Cell-based Antibody Discovery Screening Solution with the Hybridoma Mix-and-Read Screening Kit
IntelliCyt has developed a “mix-and-measure” intact cell assay for primary screening that simultaneously assesses antigen binding and cross-reactivity. This assay reduces workflow steps and increases productivity. Additionally, this approach reduces the potential for false negatives due to testing with denatured antigens.
Using the HTFC Screening System and ForeCyt Experiment Templates with the Hybridoma Mix-and-Read Screening Kit you can:
- Test for cross reactivity in your primary screen
- Make sensitive, high resolution measurements at the single cell level
- Differentiate cellular expression over a large dynamic range
- Achieve decision making results in minutes per plate
Hybridoma Mix and Read Screening Kit part numbers:
IC0K119-384 for 1-384 well plate
IC0K120-384 for 5-384 well plates
Contact us for custom sizes and pricing.
Download Application Note: Better Hybridoma Screening»
Download: HTFC Screening System for Antibody Screening»
Cell-based Antibody Clone Selection Solution with the Count and Capture IgG Screening Kit
A key component of the development of a therapeutic monoclonal antibody is the identification and selection of a manufacturing cell line that secretes high levels of the antibody into the culture supernatant. Finding a highly productive cell line is critical to the success of a potential antibody based therapeutic, because the downstream optimization and scale-up processes can be exceedingly time intensive and costly. Early identification of high producing cell lines can significantly increase the probability of success in downstream scale up activities.
Using the HTFC Screening System and ForeCyt Experiment Templates with the Count and Capture IgG Screening Kit you can:
- Reduce steps in the cell line generation process
- Provide information on specific productivity and cell health (viability)
- Enable scientists to make better decisions about which clones they should spend costly resources for further characterization
Count and Capture IgG Screening Kit part numbers:
IC0K101-384 for 1-384 well plate
IC0K102-384 for 5-384 well plates
Contact us for custom sizes and pricing.
Cell-based InVitro Toxicology Screening Solutions for Apoptosis Assays
Testing compounds and chemicals for human toxicity in cancer research, as well as Immunology and inflammation medicine has evolved over many decades beginning with early observational animal models to more recently with in vitro methods and cell-based assays. Even with the enormous amount of research in numerous fields, huge challenges still remain in identifying appropriate models to reliably predict human toxicity or adverse events.
The HTFC Screening System and our suite of Apoptosis Screening Kits can allow you to:
- Measure multiple endpoints simultaneously for single-read confidence
- Determine cell counts and viability simultaneously with specific pathway measurements
- Analyze complex mixtures of cells in the same well for differential effects