Publications

Small Molecule Discovery

Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay; Surviladze Z, Waller A, Wu Y, Romero E, Edwards BS, Wandinger-Ness A, Sklar LA. J Biomol Screen., 2010 Jan;15(1):10-20. Epub 2009 Dec 11

Detection of Intracellular Granularity Induction in Prostate Cancer Cell Lines by Small Molecules Using the HyperCyt® High-Throughput Flow Cytometry System; Mark K. Haynes, J. Jacob Strouse, Anna Waller, Andrei Leitao, Ramona F. Curpan, Cristian Bologa, Tudor I. Oprea, Eric R. Prossnitz, Bruce S. Edwards, Larry A. Sklar, Todd A. Thompson; Journal of Biomolecular Screening. 2009:596-609

High-Throughput Flow Cytometry to Detect Selective Inhibitors of ABCB1, ABCC1, and ABCG2 Transporters; Irena Ivnitski-Steele, Richard S. Larson, Debbie M. Lovato, Hadya M. Khawaja, Stuart S. Winter, Tudor I. Oprea, Larry A. Sklar, Bruce S. Edwards. Assay and Drug Development Technologies. April 1, 2008, 6(2): 263-276. 2007.

High Throughput Flow Cytometric Analysis With HyperCyt®: Utilization of a 384 Well Microplate-Based Assay for the Detection of Ligand Binding to Cellular Receptors; Linda S. Trinkle, Bruce S. Edwards, Susan M. Young, Irena Ivnitsky-Steele, Richard D. Ye, Eric R. Prossnitz, Larry A. Sklar. Poster, Society for Biomolecular Sciences (SBS) 2007

Identification of Inhibitors of Vacuolar Proton Translocating Pumps in Yeast by High-throughput Flow Cytometry Screening; Johnson RM, Allen C, Melman SD, Waller A, Young SM, Sklar LA, Parra KJ, Anal Biochem. Dec 14 (2009)

High-Throughput Screening with HyperCyt Flow Cytometry to Detect Small Molecule Formylpeptide Receptor Ligands; Susan M. Young, Crisrian Bologa, Eric R. Prossnitz, Tudor I. Oprea, Larry A. Sklar and Bruce S. Edwards. Journal of Biomolecular Screening 10(4); 2005.

Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel Small Molecule Formylpeptide Receptor Antagonists; Bruce S. Edwards, Cristian Bologa, Susan M. Young, Konstantin V. Balakin, Eric R. Prossnitz, Nikolay P. Savchuck, Larry A. Sklar, and Tudor I. Oprea. Mol Pharmacol 68:1301-1310, 2005.

A multifunctional androgen receptor screening assay using the high-throughput HyperCyt® flow cytometry system; Megan K. Dennis, Harmony J.C. Bowles, Debra A. MacKenzie, Scott W. Burchiel, Bruce S. Edwards, Larry A. Sklar, Eric R. Prossnitz, Todd A. Thompson. Cytometry Part A Volume 73A Issue 5,Pages 390-399, 2008.

Microsphere-Based Protease Assays and Screening Application for Lethal Factor and Factor Xa; Matthew J. Saunders, Heungbok Kim, Travis A. Woods, John P. Nolan, Larry A. Sklar, Bruce S. Edwards, and Steven W. Graves, Cytometry Part A 69A: 342-352, 2006.

Flow Cytometry Applications

Flow Cytometry for Biotechnology; edited by Larry A. Sklar. Oxford University Press, 2005.

Flow Cytometry for High-Throughput, High Content Screening; Bruce S. Edwards, Tudor Oprea, Eric R. Prossnitz, Larry A. Sklar. Current Opinion in Chemical Biology; 8:392-398, 2004.

An Investigation of Liquid Carry-over and Sample Residual for the HyperCyt Sample Delivery System; Bartsch, JW, Waller, A, Mammoli AA, Buranda T, Sklar LA, Tran HD, and Edwards, BS. Analytical Chem;76(13):3810-7, 2004.

High-Throughput Flow Cytometry:Validation in Microvolume Bioassays; Sergio Ramirez, Charity T. Aiken, Brett Andrzejewski, Larry A. Sklar, and Bruce S. Edwards, Cytometry Part A 53A:55-65, 2003